Sertraline (Zoloft)
With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Sertraline or a refill of an existing one.
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Estimated pharmacy cash price
from $11/moTypical cash price for generic Sertraline without using insurance. Estimates only — actual prices vary by location, quantity, and discount programs.
$14
CVS
$16
Walgreens
$11
Walmart
$15
Costco
Commonly prescribed for
What is Sertraline (Zoloft)?
Sertraline is an SSRI antidepressant that works by increasing serotonin levels in the brain. It's one of the most commonly prescribed antidepressants, used for depression, anxiety disorders, PTSD, OCD, and panic disorder. It typically takes 4-6 weeks to feel the full effects.
Selective serotonin reuptake inhibition
Blocks the reabsorption of serotonin in the brain, making more serotonin available. This helps improve mood, reduce anxiety, and regulate emotional responses.
Gradual therapeutic effect
Unlike immediate-acting medications, SSRIs work gradually over several weeks as your brain adapts to increased serotonin levels, providing sustained relief.
Well-established safety profile
Decades of clinical use have established sertraline as a safe, effective first-line treatment with a favorable side effect profile compared to older antidepressants.
Dosage & forms
Drug class: SSRI (selective serotonin reuptake inhibitor)
Typical dosing
Usually started at 25–50 mg once daily and adjusted up to 50–200 mg based on response and tolerability.
Some benefit in 1–2 weeks; full effect typically takes 4–6 weeks.
Your clinician determines the right dose and form for you. Always follow the instructions on your prescription label.
Common side effects
Most side effects are mild and often ease within the first few weeks. Tell your clinician if any are bothersome or do not go away.
Nausea
Diarrhea
Insomnia or drowsiness
Headache
Sexual side effects
Dry mouth
Important safety information
Antidepressants carry a boxed warning for increased risk of suicidal thoughts in people under 25, especially in the first weeks of treatment or after a dose change. Seek help right away if mood worsens.
Rarely, combining serotonergic medications can cause serotonin syndrome (agitation, fast heart rate, fever, tremor). Tell your clinician about every medication and supplement you take.
Do not stop suddenly — your clinician will taper the dose to avoid discontinuation symptoms such as dizziness, flu-like feelings, or 'brain zaps.'
This information is educational and not a complete list of risks. It is not a substitute for advice from your clinician or pharmacist. In an emergency, call 911. If you are in crisis, call or text 988.
Ongoing support, always available.
You'll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.
Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we'll manage dosing and monitor for side effects. You're never left to navigate care on your own.
All your care in one place. That's the Attunio difference.
We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way.
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Share what's been going on, and we'll help you understand the right next step. When you're ready, we'll coordinate everything and make sure you have clear follow-up on your results.
What our customers have to say
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